Adults only (18+)

Can HRT Cause Depression? Understanding the Relationship Between Hormone Replacement Therapy and Mood

Hormone Replacement Therapy (HRT) is commonly prescribed to alleviate symptoms of menopause by supplementing the body with oestrogen and sometimes progesterone. While HRT can significantly improve quality of life for many women, some individuals wonder if it can cause depression or mood changes. The relationship between HRT and depression is complex and varies between individuals.

How HRT Affects Mood

Hormones like oestrogen play a key role in regulating mood and brain chemistry. For many women, HRT helps stabilise mood swings, reduce anxiety and lift feelings of low mood associated with menopausal hormonal fluctuations. However, because hormones influence neurotransmitters such as serotonin and dopamine, changes in hormone levels through HRT can also affect mood in unpredictable ways.

Can HRT Cause Depression?

While HRT is generally used to improve mood, some women report experiencing depressive symptoms after starting or changing HRT. This could be due to several factors: the body adjusting to new hormone levels, the type or dose of hormones used, or individual sensitivity. In rare cases, progesterone-containing HRT has been linked to mood worsening. However, for many, HRT either improves or has no significant impact on depression.

Other Factors Influencing Mood During HRT

Mood changes during menopause or HRT may also result from external factors such as stress, sleep disturbances, physical health, or pre-existing mental health conditions. It can be difficult to separate these influences from the effects of HRT itself.

What to Do If You Experience Depression on HRT

If you notice worsening mood or depressive symptoms after starting HRT, it’s important to discuss this with your healthcare provider. They may adjust the hormone type or dose, suggest alternative treatments or recommend additional support such as counselling or medication.

Monitoring and Support

Regular follow-up during HRT treatment allows monitoring of both physical and mental health. Open communication with your doctor ensures any side effects are addressed promptly.

In Summary

HRT can affect mood positively or negatively depending on individual response. While it does not commonly cause depression, some women may experience mood changes that require medical review. If you have concerns about depression while on HRT, consult your healthcare provider for personalised advice and support.